DEFLORTIN – 1
Deflazacort 1 mg
DEFLORTIN – 6
Deflazacort 6 mg
DEFLORTIN – 12
Deflazacort 12 mg
DEFLORTIN – 18
Deflazacort 18 mg
DEFLORTIN – 24
Deflazacort 24 mg
Deflortin tablet contains deflazacort. It is a glucocorticoid which is used as anti-inflammatory and immunosuppressant. It is an inactive drug which is becomes active by metabolism to 21-desacetyldeflazacort.
- Allergic disorders
120 mg per day with the maintenance dose of 3-18mg/ day
Mechanism of action
The drug produces its action by preventing the release of chemicals which are important in immune system. These are mainly involved in immune and allergic responses which causes inflammation. By reduction in those responses inflammation is reduced. It also decreases white blood cells which are circulating in blood. It also decreases the chemicals that causes inflammation.
After oral administration it is well absorbed. After absorption it is converted by plasma esterase to its pharmacological active compound by peak plasma concentration achieving in 1.5 – 2hrs.
Nearly about 40% of the drug is bound to plasma protein. It binds to plasma protein and blood cell. It does not cross blood brain barrier and not pass through pituitary circulation.
The elimination of the drug is through kidney. About 70% of the drug is excreted through urine. 30% of the drug is excreted in feces.
- Patients taking immunosuppressant vaccine
- Hypersensitivity to any of the ingredient
- Patient with the history of adrenal suppression or infections
- Recent heart attack
- High blood pressure
- Corneal damage
- Peptic ulcer
- During pregnancy and breast feeding
- Avoid long term use of medicine
- Can cause increased risk of confusion, irritability and nightmares
- Kidney impairment
- Hepatic failure
- Suicidal thoughts