Deflortin Tablets

COMPOSITION

DEFLORTIN – 1

Deflazacort                             1 mg

DEFLORTIN – 6

Deflazacort                             6 mg

DEFLORTIN – 12

Deflazacort                             12 mg

DEFLORTIN – 18

Deflazacort                             18 mg

DEFLORTIN – 24

Deflazacort                             24 mg

Introduction

Deflortin tablet contains deflazacort.  It is a glucocorticoid which is used as anti-inflammatory and immunosuppressant. It is an inactive drug which is becomes active by metabolism to 21-desacetyldeflazacort.

 

Indication

  • Inflammation
  • Allergic disorders

 

Dosage

120 mg per day with the maintenance dose of 3-18mg/ day

 

Mechanism of action

The drug produces its action by preventing the release of chemicals which are important in immune system. These are mainly involved in immune and allergic responses which causes inflammation. By reduction in those responses inflammation is reduced. It also decreases white blood cells which are circulating in blood. It also decreases the chemicals  that causes inflammation.

 

Pharmacology

Absorption

After oral administration it is well absorbed. After absorption it is converted by plasma esterase to its pharmacological active compound by peak plasma concentration achieving in 1.5 – 2hrs.

Distribution

Nearly about 40% of the drug is bound to plasma protein. It binds to plasma protein and blood cell. It does not cross blood brain barrier and not pass through pituitary circulation.

Excretion

The elimination of the drug is through kidney. About 70% of the drug is excreted through urine. 30% of the drug is excreted in feces.

 

Contraindications

  • Patients taking immunosuppressant vaccine
  • Hypersensitivity to any of the ingredient

 

 

Precautions

  • Patient with the history of adrenal suppression or infections
  • Recent heart attack
  • High blood pressure
  • Corneal damage
  • Osteoporosis
  • Peptic ulcer
  • During pregnancy and breast feeding
  • Avoid long term use of medicine
  • Can cause increased risk of confusion, irritability and nightmares
  • Kidney impairment
  • Hepatic failure
  • Depression
  • Suicidal thoughts