Dezdin Tablets

Desloratadine   5 mg

Introduction

Dezdin tablet contains desloratadine. It is anti-histaminic which is mainly used to treat allergies.

 

Indications

  • Allergic symptoms
  • Perennial rhinitis
  • Chronic idiopathic urticaria

 

Dosage

Once daily

 

Mechanism of action

The drug produces its action by reacting with human histamine H1 receptor and inhibiting the release of histamine. Desloratadine is histamine antagonist having H1 receptor histamine antagonist activity.

 

Pharmacology

Absorption

After oral administration the drug attains its maximum plasma concentration in 3 hrs. Presence of fruit or juice does not effect the bioavailability of the drug.

Distribution

The drug is well distributed in the body and about 85-89% of the drug is bound to plasma protein. The drug is metabolized by an active metabolite to 3-hydroxydesloratadine.

Excretion  

The metabolites of the drug is excreted in urine and feces.

Contraindication

  • Hypersensitivity to any of the ingredient

 

Precautions

  • Cautiously used in lactating mothers
  • Patients with renal impairment
  • Hepatic impairment