Enclina Adp Gel


COMPOSITION:

Adapalene        0.1% w/w

Clindamycin Phosphate eq. to Clindamycin       1% w/w

 

Introduction

Enclina ADP gel contains Clindamycin and Adapalene. Clindamycin belongs to lincomycin antibiotic class of drugs which are mainly used in the treatment of bacterial infections. Adapalene  is a third generation topical retinoids (are the group of compounds produces similar action like vitamin A).

 

Indication

  • Acne
  • Acne lesions
  • Healing of pimples

 

Dosage

To be applied on effected area once in night.

 

Mechanism of action

Clindamycin

The drug produces its bacteriostatic effects by binding to the 50S unit of the rRNA of the bacteria. It inhibits the bacterial protein synthesis by stopping the translocation of the ribosomes.

Adapalene

The drug produces its action by decreasing the microcomedone (A comedo is a clogged hair follicle (pore) in the skin) formation by normalizing the differentiation in epithelial cells and thus reduces acne.

 

Pharmacology

Clindamycin

Absorption

About  4-5% of the drug is absorbed by the skin.

Distribution

The drug is well distributed in the into tissue fluids, the metabolism of the drug is through liver. During metabolism the drug is converted to sulfoxide and N-demethyl metabolites.

Excretion

The plasma half life of the drug is 2-3 hrs. Approximately 10% of the drug is excreted through urine and 4% in feces.

Adapalene

Absorption

After local application the amount of drug absorbed by the skin is very low.

Excretion

Elimination half life of the drug is 7-51 hrs. The excretion of the drug is through bile.

 

 

Contraindications

  • Hypersensitivity to any of the ingredient or lincomycin antibiotic

 

Precautions

  • Pregnant and lactating patients
  • Regular analysis of renal and hepatic function to be made regularly if the therapy is prolonged.
  • Not intended for broken eczematous skin