Adapalene 0.1% w/w
Clindamycin Phosphate eq. to Clindamycin 1% w/w
Enclina ADP gel contains Clindamycin and Adapalene. Clindamycin belongs to lincomycin antibiotic class of drugs which are mainly used in the treatment of bacterial infections. Adapalene is a third generation topical retinoids (are the group of compounds produces similar action like vitamin A).
- Acne lesions
- Healing of pimples
To be applied on effected area once in night.
Mechanism of action
The drug produces its bacteriostatic effects by binding to the 50S unit of the rRNA of the bacteria. It inhibits the bacterial protein synthesis by stopping the translocation of the ribosomes.
The drug produces its action by decreasing the microcomedone (A comedo is a clogged hair follicle (pore) in the skin) formation by normalizing the differentiation in epithelial cells and thus reduces acne.
About 4-5% of the drug is absorbed by the skin.
The drug is well distributed in the into tissue fluids, the metabolism of the drug is through liver. During metabolism the drug is converted to sulfoxide and N-demethyl metabolites.
The plasma half life of the drug is 2-3 hrs. Approximately 10% of the drug is excreted through urine and 4% in feces.
After local application the amount of drug absorbed by the skin is very low.
Elimination half life of the drug is 7-51 hrs. The excretion of the drug is through bile.
- Hypersensitivity to any of the ingredient or lincomycin antibiotic
- Pregnant and lactating patients
- Regular analysis of renal and hepatic function to be made regularly if the therapy is prolonged.
- Not intended for broken eczematous skin