Enclina Gel


COMPOSITION:

Clindamycin Phosphate eq. to Clindamycin         1% w/w

Nicotinamide         4% w/w

 

Introduction

Enclina gel contains Clindamycin and Nicotinamide.  Clindamycin belongs to lincomycin antibiotic class of drugs which are mainly used in the treatment of bacterial infections. Nicotinamide  is a dietary supplement which is also called as niacinamide. It is a amide of nicotinic acid.

 

 

Indications

  • Acne
  • Acne lesions

 

Dosage

The drug to be applied on the effected surface of the cream twice a day.

 

 

Mechanism of action

The drug produces its bacteriostatic effects by binding to the 50S unit of the rRNA of the bacteria. It inhibits the bacterial protein synthesis by stopping the translocation of the ribosomes.

 

Pharmacology

Absorption

About  4-5% of the drug is absorbed by the skin.

Distribution

The drug is well distributed into tissue fluids, the metabolism of the drug is through liver. During metabolism the drug is converted to its active metabolite i.e sulfoxide and N-demethyl metabolites.

Excretion

The plasma half life of the drug is 2-3 hrs. Approximately 10% of the drug is excreted through urine and  4% in feces.

 

Contraindication

  • Hypersensitivity to any of the ingredient or lincomycin antibiotic

 

Precaution

  • Hepatic impairment
  • Renal impairment
  • Pregnant and lactating patients
  • Regular analysis of renal and hepatic function to be made regularly if the therapy is prolonged.