Clindamycin Phosphate eq. to Clindamycin 1% w/w
Nicotinamide 4% w/w
Enclina gel contains Clindamycin and Nicotinamide. Clindamycin belongs to lincomycin antibiotic class of drugs which are mainly used in the treatment of bacterial infections. Nicotinamide is a dietary supplement which is also called as niacinamide. It is a amide of nicotinic acid.
- Acne lesions
The drug to be applied on the effected surface of the cream twice a day.
Mechanism of action
The drug produces its bacteriostatic effects by binding to the 50S unit of the rRNA of the bacteria. It inhibits the bacterial protein synthesis by stopping the translocation of the ribosomes.
About 4-5% of the drug is absorbed by the skin.
The drug is well distributed into tissue fluids, the metabolism of the drug is through liver. During metabolism the drug is converted to its active metabolite i.e sulfoxide and N-demethyl metabolites.
The plasma half life of the drug is 2-3 hrs. Approximately 10% of the drug is excreted through urine and 4% in feces.
- Hypersensitivity to any of the ingredient or lincomycin antibiotic
- Hepatic impairment
- Renal impairment
- Pregnant and lactating patients
- Regular analysis of renal and hepatic function to be made regularly if the therapy is prolonged.