Erbina 250 Tablets

COMPOSITION:

Terbinafine        250 mg

Introduction

Erbina tablet contains terbinafine. Terbinafine  is a synthetic allyamine antifungal drug which mainly used to treat  fungal infection of the skin.

Indication

  • Skin fungal infection
  • Pityriasis versicolor (eruptions or patches on skin)
  • Fungal infections on nails
  • Onychomycosis of toe nails or finger nail (thickened, brittle, crumbly or ragged nails.)

Dosage

Once daily for 6 to 12 weeks. (Duration of  the use of the drug depends on type of infection)

Mechanism of action

The drug produces its fungicidal action by blocking the essential component present in the fungal cell membrane  i.e ergosterol by inhibiting the sequence of monooxygenase . Thus the decreased amount of ergosterol and monooxygenase causes accumulation of the sequences and contributes to its anti-fungal activity.

Pharmacology

Absorption

The drug after oral administration gets absorbed by the gastrointestinal tract

Distribution

About 99% of the drug is bound to the plasma protein and metabolism of the drug is through hepatic enzymes i.e cytochrome P 450. The drug attains its half life in 36 hrs.

 Excretion

About 70%  of the drug is excreted through urine.

Contraindications

  • In patients with previous allergic reaction

Precautions

  • Hepatotoxicity
  • Alteration in taste
  • Can cause some depressive symptoms
  • Loss of smell
  • Immunodeficient patient should be regular monitored for their blood count. The drug can cause decease in absolute lymphocyte counts.

(Low absolute lymphocyte indicates some disorder in the body.)