Erbina Cream


COMPOSITION:

Terbinafine  Hydrochloride BP  1% w/w

Introduction

Erbina cream contains terbinafine. Terbinafine  is a synthetic allyamine antifungal drug which mainly used to treat  fungal infection of the skin.

 

Indication

  • Skin fungal infection
  • Pityriasis versicolor (eruptions or patches on skin)
  • Fungal infections on nails
  • Onychomycosis of toe nails or finger nail (thickened, brittle, crumbly or ragged nails.)

 

Dosage

Twice daily until a significant clinical improvement and not to be used more than four weeks.

 

Mechanism of action

The drug produces its fungicidal action by blocking the essential component present in the fungal cell membrane  i.e ergosterol by inhibiting the sequence of monooxygenase . Thus the decreased amount of ergosterol and monooxygenase which causes accumulation of the sequences and contributes to its anti-fungal activity.

 

Pharmacology

Absorption

The drug after topical application rapidly gets absorbed by the skin

 

 

Distribution

About 99% of the drug is bound to the plasma protein and metabolism of the drug is through hepatic enzymes i.e cytochrome P 450. The drug attains its half life in 36 hrs.

 Excretion

About 70%  of the drug is excreted through urine.

 

Contraindications

  • In patients with previous allergic reaction

 

Precautions

  • Hepatotoxicity
  • Alteration in taste
  • Can cause some depressive symptoms
  • Loss of smell
  • Immunodeficient patient should be regular monitored for their blood count. The drug can cause decease in absolute lymphocyte counts.

(Low absolute lymphocyte indicates some disorder in the body.)