LAZULI LOTION 15ML

Packing

15 ml  In Outer Carton

Composition

Luliconazole   1% w/v

Description

 

Lazuli 1% is an azole antifungal agent. It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane and weakening it.

 

Indications

  • Preventing growth of the fungus
  • Interdigital tinea pedis,
  • Tinea cruris,
  • Tinea corporis

Dosage

When treating interdigital tinea pedis, Lazuli lotion applied to affected area once daily for two (2) weeks.
When treating tinea cruris or tinea corporis, Lazuli lotion, 1% should be applied to the affected area once daily for one (1) week.

 

Mechanism of Action

Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.

 

Pharmacology

Absorption- Topical application of luliconazole 1% cream to skin, low concentrations are absorbed systemically.

Distribution- Not known whether distributed into milk following topical application of 1% cream.Plasma Protein Binding >99%.

Metabolism- systemically absorbed luliconazole may be metabolized by CYP2D6 and 3A4, Half-life-Mean plasma half-life was 21.1 or 32.4 hours on day 15 of once-daily topical application of 1%

Contraindications

  • Hypersensitivity
  • Pregnancy & Nursing Mothers

Precaution

  • Allergic to azole antifungals
  • For topical use only
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