Presza 50 Tablets
Azathioprine 50 mg
Presza 50 tablet contains azathioprine. It is an immunosuppressant drug which produces its action by suppressing the response of immune system.
- Skin rashes
- Severe inflammatory skin diseases
- Atopic dermatisis (Itchy red skin occurs in childhood occurs near by arms or knees)
- Sarcoidosis (Inflammation of the cells causes lumps)
- Eczema (Patchy or itchy skin which usually gets inflamed and even bleeds)
Doses of the are as follows:
Atopic dermatitis: 2.5 mg/kg orally once a day, in the morning, for 3 months
Sarcoidosis: 2 mg/kg per day in combination with prednisolone 0.6 to 0.8 mg/kg per day
Eczema: 2.5 to 3.5 mg/kg per day
Mechanism of action
The drug produces its immunosuppressant action by inhibiting the synthesis of protein, DNA and RNA. It also interferes with the mitosis by effecting cellular metabolism. Azathioprine produces its action by changing the structure of DNA due to the incorporation of thiopurine analogue.
The drug after oral administration absorbs well in the body. The drug attains its maximum serum concentration within 1 to 2 hrs.
The drug gets converted to its active metabolite by non- enzymatic process to metabolite 6 – mercaptopurine. Hypoxanthine-guanine phosphoribosyltransferase causes the activation of the metabolite to form thioguanine nucleotides (6-TGNs) as a metabolite by involving multiple enzymatic processes involving kinase.
In erythrocytes and liver the drug gets methylated or oxidized and gets rapidly eliminated from blood. The drug after 8 hrs are is not detectable in urine.
- Hypersensitivity to any of the ingredient
- Not be used for the treatment of the patients suffering from rheumatoid arthritis
- Discontinue the use of the drug if suffering from gastrointestinal hypersensitivity reaction characterized by nausea and vomiting.
- Patient should be under regular analysis for complete blood count
- Not to administered to pregnant patients
- Not to be used in pediatric patient