Clobetasol propionate 0.05% w/w
Fusidic acid 2% w/w
Sterk-FD cream contains Clobetasol propionate and fusidic acid. Clobetasol propionate is a corticosteroid of glucocorticoid class. It is used for the management of skin related disorders which includes eczema or psoriasis. It is the most potent glucocorticoid. Fuscidic acid is a bacteriostatic drug which mainly used in the topical preparations.
- Reduces the skin itching and redness
- Skin inflammation
- Severe bacterial infection
Twice daily for a period of 3-4 weeks
Mechanism of action
It produces inflammatory action by acting on induction of phospholipase A2 inhibitory protein which is called as lipocortins. These proteins produce control over biosynthesis of mediators of inflammation i.e PGs and leukotrienes. This causes inhibition of arachidonic acid. Clobetasol binds to glucocorticoid receptor which complexes, enters the nucleus of cell and modifies genetic transcription.
The drug produces its bacteriostatic action by inhibiting the synthesis of protein by disrupting the translocation of peptide subunits and elongation in the peptide chain of the bacteria.
After topical application it is well absorbed by the skin. The absorption of the drug depends on the vehicle used in formulation of ointment.
It is well distributed and metabolized by the liver.
The excretion of the drug is through kidney; its metabolites are also excreted in bile.
Hypersensitivity to any of the ingredients in the preparations
- Can produce reversible HPA axis suppression so regularly evaluated
- Glucocorticosteroid insufficiency after withdrawal from treatment
- Glucosuria in some patients
- Systemic toxicity in pediatric patients
- Local application can cause irritation, so patient should discontinue
- Skin infections