Clobetasol propionate 0.05% w/w
Salicylic acid 3% w/w
Sterk-S3 ointment contains Clobetasol propionate and Salicylic acid. Clobetasol propionate is a corticosteroid of glucocorticoid class. It is used for the management of skin related disorders which includes eczema or psoriasis. It is the most potent glucocorticoid. Salicylic acid is a type of phenolic acid used to remove the outer layer of the skin. It is a potent keratolytic agent.
- Reduces the skin itching and redness
- Skin inflammation
- Severe bacterial infection
Twice daily for a period of 3-4 weeks
Mechanism of action
It produces inflammatory action by acting on induction of phospholipase A2 inhibitory protein which is called as lipocortins. These proteins produce control over biosynthesis of mediators of inflammation i.e PGs and leukotrienes. This causes inhibition of arachidonic acid. Clobetasol binds to glucocorticoid receptor which complexes, enters the nucleus of cell and modifies genetic transcription.
It produce its anti-inflammatory action by suppressing the enzyme responsible for producing inflammatory mediators which causes inflammation.
After topical application it is well absorbed by the skin. The absorption of the drug depends on the vehicle used in formulation of ointment.
It is well distributed and metabolized by the liver.
The excretion of the drug is through kidney; its metabolites are also excreted in bile.
After topical application the drug is well absorbed by the skin
About 50-80% of the drug is bound to plasma protein
The drug is excreted through urine
- Patients with impaired circulation in the blood
- Not to be used on broken skin
- Sensitivity test should be done if using it first time
- Regular monitoring for any toxicity