Sterk S6 Ointment

COMPOSITION

Clobetasol propionate                        0.05% w/w

Salicylic acid                                       6% w/w

Introduction

Sterk- S6 ointment contains Clobetasol propionate and Salicylic acid. Clobetasol propionate is a corticosteroid of glucocorticoid class. It is used for the management of skin related disorders which includes eczema or psoriasis. It is the most potent glucocorticoid. Salicylic acid is a type of phenolic acid used to remove the outer layer of the skin. It is  a potent keratolytic agent.

 

Indications

  • Reduces the skin itching and redness
  • Skin inflammation
  • Severe bacterial infection

 

Dosage

Twice daily for a period of 3-4 weeks

 

Mechanism of action

Clobetasol propionate

It produces inflammatory action by acting on induction of phospholipase A2 inhibitory protein which is called as lipocortins. These proteins produce control over biosynthesis of mediators of inflammation i.e PGs and leukotrienes. This causes inhibition of arachidonic acid. Clobetasol binds to glucocorticoid receptor which complexes, enters the nucleus of cell and modifies genetic transcription.

 

 

Salicylic acid

It produce its anti-inflammatory action by suppressing the enzyme responsible for producing inflammatory mediators which causes inflammation.

 

Pharmacology

Clobetasol propionate

Absorption

After topical application it is well absorbed by the skin. The absorption of the drug depends on the vehicle used in formulation of ointment.

Distribution

It is well distributed and metabolized by the liver.

Excretion

The excretion of the drug is through kidney; its metabolites are also excreted in bile.

Salicylic acid

Absorption

After topical application the drug is well absorbed by the skin

Distribution

About 50-80% of the drug is bound to plasma protein

Excretion

The drug is excreted through urine

 

 

Contraindications

  • Patients with impaired circulation in  the blood

 

 

Precautions

  • Not to be used on broken skin
  • Sensitivity test should be done if using it first time
  • Regular monitoring for any toxicity