Atarol Tablets


Loratadine    10 mg


Loratadine is a second generation histamine antagonist drug which is mainly used to treat allergies. It is closely related to tricyclic antidepressant and is related to atypical antipsychotic quetiapine. It is non sedative properties. It reduces the effect of natural chemical histamine in the body. Loratadine is used to treat skin hives and itching in people with chronic skin reactions.


  • Skin rashes
  • Hives
  • Allergic skin reaction



10 mg once daily or 5 mg 12 hrly.


Mechanism of action

Loratidine acts on free histamine and exhibits specific peripheral H1 antagonist activity. This blocks the action of histamine and causes relief of negative symptoms occurs by histamine. It has low affinity for cholinergic receptor and has no alpha-adrenergic blocking activity. It suppresses the release of histamine and leukotrienes from mast cells.




It gets rapidly absorbed by the body after oral administration with bioavailability about 40%


97-99% of the drug is protein bound and metabolism is through CYP 450


In urine and feces, the drug is excreted in the form of metabolites.



  • Patients with hypersensitivity to this medication



  • Hepatic and renal impairment
  • In nursing mothers because drug passes into the breast milk